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OpenUrlCrossRefPubMedWeb of ScienceIto KLim S, Caramori G, et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Theophylline restores histone deacetylase activity and steroid responses in Socks compression macrophages. A mechanism of corticosteroid resistance in COPD: inactivation of histone deacetylase.

Socks compression of ScienceIto KБольше информации T, Barnes PJ, et al. Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: role of tyrosine nitration.

OpenUrlCrossRefPubMedWeb of ScienceIchinose MSugiura H, Yamagata S, et al. Increase in reactive nitrogen species socks compression in chronic obstructive pulmonary disease airways. OpenUrl Supplementary materials Related Data Footnotes Competing interests: none declared. Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic socks compression. Other types of articles such as reviews, editorials, a few special articles of interest to the society and the editorial board, scientific letters, letters to the Editor, and clinical images are also socks compression in the Journal.

It is a monthly Journal that publishes a total of 12 issues and a few supplements, which contain articles belonging to the different sections. The Journal is published monthly both socks compression Spanish and English. Therefore, the submission of manuscripts written in either Spanish socks compression English is welcome.

Translators working for the Journal are in charge of the corresponding translations. Access to any published article, in either language, is possible through the Journal's web page as well as from PubMed, Science Direct, and other international databases.

Furthermore, the Journal is also present in Twitter and Facebook. The Journal expresses the voice of the Spanish Respiratory Society socks compression Pulmonology and Thoracic Surgery (SEPAR) as well as that of other scientific societies such as socks compression Latin American Thoracic Society (ALAT) and the Iberian American Association of Thoracic Surgery (AICT). Authors are also welcome to submit their articles to the Journal's open access companion title, Open Respiratory Archives.

Theophylline, which is inexpensive and widely available, remains one of the most commonly prescribed drugs worldwide for the treatment of asthma and COPD. Oral theophylline has been used in COPD for its bronchodilatory properties for more than 70 years. Its mechanism of action is based on the non-selective inhibition of phosphodiesterase and the increase of intracellular cAMP, which relaxes the smooth muscle of the airways. For all these reasons, it is not surprising that high-dose theophylline has gradually been replaced by inhaled bronchodilators.

In 2002, Ito et al. This new anti-inflammatory effect is a result of increased histone deacetylase (HDAC) activity that socks compression the socks compression effect of glucocorticoids by decreasing the expression of proinflammatory genes. However, few studies are available on the clinical effects of low-dose theophylline in vivo, and results are variable. The administration of oral socks compression theophylline in patients with COPD exacerbations significantly reduced HDAC activity in sputum macrophages at 3 months, and could be due to the concomitant administration socks compression oral corticosteroids.

This study was unable to confirm in vivo any increase socks compression HDAC activity, the molecular antiinflammatory effect previously observed in vitro5. In any case, because of its modest bronchodilatory effect, and controversial evidence of the oral antiinflammatory effect, and narrow therapeutic range, theophylline is a third-line treatment in current clinical practice guidelines,12,13 and its use is reserved socks compression a привожу ссылку option in severely ill patients who do not respond to conventional drugs.

Does this point to the end socks compression theophylline. The socks compression of the drug and the numerous in vitro and ex vivo studies that show improvements in the anti-inflammatory efficacy of corticosteroids socks compression combined with low-dose theophylline oblige us, at least, to look for new routes of administration, which might perhaps include the combined administration of the two drugs by inhalation, to confirm if the in vitro effects socks compression also socks compression in clinically relevant flovent. Until then, theophylline in COPD will probably continue to be the last option in severely ill patients who fail to respond to previous treatment lines.

Menjoge, UPLIFT Study Investigators, et al. A 4-year trial of tiotropium продолжение здесь chronic obstructive pulmonary disease. N Engl J Med, 359 (2008), pp. Am J Respir Crit Care Med, 188 (2013), pp. Global strategy socks compression the diagnosis management, and prevention of chronic obstructive pulmonary disease GOLD executive summary. Am J Respir Crit Care Med, 176 (2007), pp.



15.05.2020 in 18:33 Федосья:
Браво, какие нужные слова..., блестящая мысль

22.05.2020 in 08:03 Регина:
Искал реферат в Яндексе, и набрел на эту страницу. Немного информации по моей теме реферата набрал. Хотелось бы побольше, да и на том спасибо!

23.05.2020 in 22:19 gafastcons:
Присоединяюсь. Это было и со мной. Давайте обсудим этот вопрос.