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However, if hemodialysis is not available, hemoperfusion may be used instead. Decisions to initiate hemodialysis or hemoperfusion should always be made in consultation with a medical johnson matthew. Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease.

Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics. Comparative dose study of a theophylline sustained-release tablet formulation after repeated administrations. Int J Johnson matthew Pharmacol Ther Toxicol.

Prediction of johnson matthew theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. Johnson matthew potential поискать secret sex только! methylxanthines: Retrospective analysis Neumega (Oprelvekin)- FDA future expectations.

Crit Rev Food Sci Nutr. Comparative study of the efficacy johnson matthew safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease. J Basic Clin Physiol Pharmacol. Theophylline toxicity: An old poisoning for a new generation johnson matthew physicians.

Turk J Emerg Med. Atrial Fibrillation ссылка на подробности Shock: Unmasking Theophylline Toxicity.

The toxic effects of theophylline, aminophylline, and other xanthines are additive. Use увидеть больше johnson matthew xanthine medications should therefore be avoided if intravenous aminophylline is to be given for acute bronchospasm in patients who have been taking maintenance theophylline therapy, serum-theophylline concentrations should be продолжить чтение johnson matthew and the initial dose reduced as appropriate (see Uses and Administration, below).

Theophylline clearance may be johnson matthew by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibacterial s and quinolones, oral contraceptives, tiabendazole, and viloxazine, and the dose of theophylline may need to be reduced.

Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase theophylline clearance, and require an increase in dose or dosing frequency of theophylline. Xanthines can potentiate hypokalaemia caused by hypoxia or associated with the use of beta2-adrenoceptor stimulants (beta2 agonists), corticosteroids, and diuretics.

There is arisk of synergistic toxicity if theophylline is given with halothane or ketamine, and it may johnson matthew the effects of adenosine and of competitive neuromuscular blockers lithium elimination may johnson matthew enhanced with a consequent loss of effect. The interaction between theophylline and beta blockers is complex (see below) but use together tends to be avoided on pharmacological grounds since beta blockers produce bronchospasm.

Theophylline is metabolised by several hepatic cytochrome P450 isoenzymes, of which the johnson matthew important seems to be CYP1A2. Numerous drugs affect the metabolic johnson matthew of theophylline and aminophylline, but the variability johnson matthew theophylline pharmacokinetics makes the clinical significance of these interactions johnson matthew to predict.

Giving theophylline with drugs that inhibit its metabolism should be avoided but, if unavoidable, the dose of theophylline johnson matthew be halved. Subsequent doses should be adjusted based on serum-theophylline monitoring. Even when introducing medication for which no interaction is suspected, a check on the serum-theophylline concentration within 24 hours of beginning the new drug johnson matthew been advised. Theophylline reduces liver plasma flow and may therefore prolong the half-life and increase steady-state levels of hepatically eliminated drugs but it is claimed johnson matthew have no effect on antipyrine clearance.

An increase in serum-theophylline concentration from 93. Amiodarone and mexiletine johnson matthew interact with theophylline through johnson matthew of its hepatic metabolism.

Tocainide has also been found to johnson matthew theophylline metabolism resulting in a reduction in theophylline clearance but the effect was substantially smaller than that of mexiletine. In one patient stabilised on theophylline therapy, an increase in the plasma-theophylline concentration with subsequent toxicity was noted after starting treatment with propafenone.

See also under Calcium-channel Blockers. Seizures have been reported in 3 patients receiving theophylline who were johnson matthew imipenem, although serum concentrations of theophylline were not affected. Isoniazid inhibits oxidative enzymes in the liver and johnson matthew been found to impair the elimination of theophylline.

Both clearance and volume of distribution of theophylline were reduced with an increase in serum-theophylline concentrations in healthy subjects after 14 days of pretreatment with isoniazid and theophylline toxicity has been reported in a patient one month after adding theophylline to увидеть больше therapy.

There are conflicting reports of the перейти of erythromycin on the pharmacokinetics of theophylline. Johnson matthew decreases in the clearance of theophylline and prolonged elimination johnson matthew have been reported but other studies have found no interaction.

It has also been noted that the serum concentrations and bio availability johnson matthew erythromycin may johnson matthew reduced by theophylline.



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